Preparation and characterization of PLGA–lipid hybrid nanoparticles for controlled release of N-acetyl cysteineto lung cancer cells

Preparation and characterization of PLGA–lipid hybrid nanoparticles for controlled release of N-acetyl cysteineto lung cancer cells

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Part of #Preparation and characterization of PLGA–lipid hybrid nanoparticles for controlled release of N-acetyl cysteineto lung cancer cells# :

Publishing year : 2015

Conference : International Conference on Engineering and Applied Sciences

Number of pages : 16

Abstract: The use of liposomal and biodegradable polymeric nanoparticles (NPs) to expose and deliver therapeutic compounds has increased due to clinically demand. In this study, we focused on the new hybrid carrier; Poly (D, L-lactide-co-glycolide) (PLGA) -lecithin nanoparticles for controlled release of N-acetyl cysteine (NAC) to the lung cancer cell line. These core-shell NPs consist of (i) a PLGA hydrophobic core, and (ii) a soybean lecithin mono-layer shell, and were synthesized by a nanoprecipitation combined with a self-assembly method. Nanoparticles were characterized in terms of surface morphology, FTIR spectroscopy, size distribution, in vitro drug release by high performance liquid chromatography (HPLC) and differential scanning calorimetry (DSC). The results indicate that the hybrid NPs around the hr are releasing NAC versus hr for PLGA NPs. To evaluate the nanoparticles' cytotoxicity, a cell cytotoxicity test was performed on the Cor L human epithelial lung cancer cell line and showed cell viability at NPS. Our data suggest that the PLGA-lipid core-shell NPs may be a useful new controlled release drug delivery system.