In Silico Determination and Validation of PorA Structure and Ligand Binding Site as a vaccine candidate in Neisseria meningitidis

In Silico Determination and Validation of PorA Structure and Ligand Binding Site as a vaccine candidate in Neisseria meningitidis

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Part of #In Silico Determination and Validation of PorA Structure and Ligand Binding Site as a vaccine candidate in Neisseria meningitidis# :

Publishing year : 2015

Conference : Second International Conference on Science and Technology

Number of pages : 17

Abstract: Neisseria meningitidisis is a major cause of bacterial meningitis and septicemia worldwide. In the framework of a comprehensive vaccine against this organism, characterization of its variable surface antigens is important for epidemiological monitoring and vaccine development. The serologic characterization scheme for meningococci comprises the following: groups based on variations in the capsular polysaccharide; Types, based on variations of the PorB outer membrane protein (OMP); Subtypes based on variants of the PorA OMP; And immunotypes, based on variants in lipopoligosaccharide. Therefore, the development of an effective vaccine against serogroup B strains, which has been responsible for most infections in temperate states, may therefore require alternative approaches. The two major components of the OMV vaccine Are the meningococcal porin proteins encoded by porAnd porBgenes. In order to study the vaccine potential of individual outer membrane proteins, we analyze the PorB structure to identify the functional residues that are in the ligand bindig site.