Transdermal Nitroglycerin Delivery using Acrylic Matrices: Design, Formulation, and In-Vitro Characterization

Transdermal Nitroglycerin Delivery using Acrylic Matrices: Design, Formulation, and In-Vitro Characterization

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Part of #Transdermal Nitroglycerin Delivery using Acrylic Matrices: Design, Formulation, and In-Vitro Characterization# :

Publishing year : 2006

Conference : 11th National Congress of Chemical Engineering of Iran

Number of pages : 12

Abstract: Transdermal systems are among the novel drug delivery systems and are attributed to the systems having the property of diffusing drugs through the skin in a noninvasive form by delivering drugs to the systemic blood circulation, which as a consequence of drug effects appears. Constant blood levels, non-hepatic first pass effect, tolerance compliance are the advantages of these systems compared to oral administration and intravenous infusion. The present research was designed to evaluate various new Iranian drug-in-adhesive formulations of nitroglycerin transdermal patches for the treatment of angina pectoris. The target was to design drug-in-adhesive patches (DIAPs); a full factorial design was used. Different types and amounts of pressure-sensitive adhesives (PSAs), chemical permeation enhancers (CPEs) were used and evaluated with respect to drug release
and adhesive properties. A simple but precise method, the 180 Test Peel and the Probe Tack Test, was developed to measure and compare the adhesive properties of transdermal patches. Addition of CPEs has led to a decrease in the mechanical properties of PSA, which can produce some difficulties in the production of transdermal systems. In-Vitro release profiles of nitroglycerin from different formulations depended on viscosity and
Type of pressure sensitive adhesive and type and concentrate are selected chemical permeation enhancer. The results showed that release kinetics were obeyed to the square root of time or Higuchi model, indicating diffusion controlled release mechanism. It was found that the amount of nitroglycerin needed for each 15 cm2 one-day DIAP should be 40 mg. It was concluded that acrylic PSAs showed good adhesion and release
properties.