Synthesis of Some Novel 8-Amino Coffeinyl Hydroxyl Alkyl Derivatives as Potential Chemotherapeutic Agents

Synthesis of Some Novel 8-Amino Coffeinyl Hydroxyl Alkyl Derivatives as Potential Chemotherapeutic Agents

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Part of #Synthesis of Some Novel 8-Amino Coffeinyl Hydroxyl Alkyl Derivatives as Potential Chemotherapeutic Agents# :

Publishing year : 2016

Conference : The 2nd International Conference on New Findings in Chemistry and Chemical Engineering

Number of pages : 5

Abstract: The design and synthesis of some novel 8-amino coffeinyl hydroxyl alkyl derivatives as new analogues of cafaminol is described. The synthesis of these compounds was achieved in two to three steps. Initially, treatment with caffeine with N-bromosuccinimide provided the prerequisite for 8-bromocaffein. Then, the reaction of 8-bromocaffein with various commercial and / or synthesized amino alcohols was achieved to afford the corresponding 8-amino-caffeine derivatives as potent chemotherapeutic agents in good to excellent yields.